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Flunarizine
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Basic Information:Flunarizine (trade name Sibelium) a calcium channel blocker, appears to be the most effective drug in treating Alternating Hemiplegia of Childhood. Flunarizine reduces the severity and duration, but rarely the frequency.
Information:Interaction
Phenytoin, carbamazepine, valproic acid: Decrease efficacy of flunarizine.
Adverse Effect & Precaution
Epigastric distress, nausea, weigh gain, headache, drowsiness, insomnia and depression. Extra pyramidal effects, skin rash.
Precations
Not to drive and operate machinery.
Pregnancy: Contraindicated.
Breast Feeding: Contraindicated.
Man: May be given in reduced dose.
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